The White House's top spokesman refused on Wednesday to condemn the company or its top executive, whose father is a Democratic senator, for dramatically increasing the price of EpiPens.

"As it relates to this specific issue, you know, obviously I'm not going to make specific comment or specifically second-guess the pricing strategy or the business practices of one private enterprise," Josh Earnest, President Obama's press secretary, said on Wednesday.

He was reacting to reports that Mylan N.V. had boosted the price of the life-saving allergy shot 400 percent, to roughly $500 per dose. Earnest and other officials have had more violent reactions to similar price spikes in the healthcare industry that have often been blamed on corporate greed.

Earnest also had no comment on the fact that Mylan CEO Heather Bresch is the daughter of Sen. Joe Manchin, D-W.Va.

"It's not clear to me now, at least based only on what I've read in … news reports, that there's any correlation or any connection. But I assume that's something that you and your news organizations will be taking a look at," Earnest said.

Earnest wouldn't say that Mylan was out of line for bumping the price of EpiPens. But he did say that companies that boast about life-saving medication "often do real damage to their reputation by being greedy and jacking up prices in a way that victimizes vulnerable Americans."

"And I think it raises significant questions, even moral questions, in the minds of a lot of people," he said about unscrupulous price hikes.

"So we certainly have seen other high-profile incidents of pharmaceutical companies that have taken a hit both to their reputation and their stock price for engaging in unscrupulous practices," Earnest said. "And I think other companies, including other pharmaceutical companies, would be wise to learn those lessons."