Marco Rubio went on the attack against Donald Trump on Sunday in Roanoke, Va., calling into question GOP front-runner's hands, among other things.

In response to Trump chiding Rubio for sweating, Rubio told the crowd that Trump doesn't sweat "because his pores are clogged from the spray tan he uses."

"Donald is not going to make America great. He's going to make America orange," Rubio quipped.

Rubio told the audience that he gets why Trump likes to call him "Little Marco," because the billionaire casino tycoon is taller than him at what he guessed to be 6-foot-2.

"Which is why I don't understand why his hands are the size of someone who is 5'2". Have you seen his hands? They're like this," Rubio said, putting up a claw-like gesture before the audience.

"And you know what they say about men with small hands," he said. "You can't trust them."

Rubio isn't the first person to mock Trump's hands.

Graydon Carter, editor at Vanity Fair, has called Trump a "short-fingered vulgarian."