Donald Trump immediately went after his Democratic opponent on Monday during a speech in Detroit, telling Americans they can expect to see more devastating economic effects on cities like Michigan's once bustling industrial metropolis if Hillary Clinton becomes president.

"The city of Detroit is the living, breathing example of my opponent's failed economic agenda," Trump told a boisterous crowd at the Detroit Economic Club, where multiple protesters interrupted his remarks.

"Detroit tops the list of most dangerous cities in terms of violent crime," he continued. "These are the silenced victims whose stories are never told by Hillary Clinton, but victims whose suffering is no less real or permanent."

Jobs Displaced by the Trans-Pacific Partnership in 2015 Graphiq

Trump has struggled to focus his attacks on Clinton in the weeks since both parties held their national conventions, but he took a hammer to the former secretary of state on Monday.

The Republican presidential nominee continued to lay out the argument that he and other GOP leaders have stuck with this cycle. He claimed Clinton's economic policies would be no different than the Obama administration's "job-killing, tax-raising, poverty-inducing" agenda.

"The one common feature of every Hillary Clinton idea is that it punishes you for working and doing business in the United States. Every policy she has tilts the playing field towards other countries at our expense," Trump said.