David Plouffe said he thinks Donald Trump's behavior meets the 'clinical definition' of a 'psychopath.'

During an appearance on NBC's "Meet the Press," the architect of President Obama's 2008 presidential campaign did not hold anything back in his criticism of the GOP nominee's fitness for office.

"I mean, basically, we have a psychopath running for president," Plouffe told NBC. "I mean, he meets the clinical definition, okay?"

Asked by NBC's Chuck Todd whether it was fair for someone without a degree in psychology to diagnose someone's mental state on air, Plouffe doubled down.

"Listen, the grandiose notion of self-worth, pathological lying, lack of empathy and remorse," Plouffe said on "Meet the Press." "I don't have a degree in psychology...but here it is: Chuck, basically, the race ends today. I think Hillary Clinton is guaranteed at least 269 electoral votes — think about that. Because Virginia and Colorado, both campaigns, I think, believe [they] are put away."

Plouffe's decision to spotlight Trump's mental state comes after several Trump supporters — including Fox News' Sean Hannity — have questioned Clinton's health and physical wellbeing.