For Democratic Senate candidate Kyrsten Sinema, Arizona appears to be the butt of all jokes. This could be a problem considering, you know, she’s running for U.S. Senate in Arizona.

A video released Friday by the Republican Senate Leadership Fund shows the Democratic congresswoman referring to the state where she’s running to replace outgoing Sen. Jeff Flake, R-Ariz., as the “meth lab of democracy.”

“The states are the laboratory of democracy,” she is seen saying in the video. “And then my state – Arizona – is the clearly the meth lab of democracy. And I did not write that line. Someone at the Daily Show wrote it, but I’m happy to steal it and use it all the time.”

In an age when drug and substance abuse have reached epidemic proportions, that’s probably not the best gag line, especially for someone who wants to be a Senator. But put the content of the joke aside for a moment. The real problem here is that Sinema delivered her remarks during an address in Las Vegas at the 2010 Netroots Nation gathering. It’s one thing to rib your constituents. It’s another thing entirely to rag on your state to outsiders:

The “meth lab” video comes just days after the release of a separate tape showing Sinema referring to both Arizona and the people who live in it as “crazy,” and advising Texans how they can "stop your state from becoming Arizona."

"Over the past several years, people would watch what's going on in Arizona and be like, 'Damn, those people are crazy,'" Sinema said in the video released earlier this week. "Is it something with the water? No, the water's fine, we stole it from Colorado."

This seems not so much like good-natured joking as it is an attempt to ingratiate herself with outside liberal audiences at the expense of the voters she now wants to make her a senator. Naturally, Republicans are taking full advantage of her carelessness.

“If Kyrsten Sinema thinks Arizonans are ‘crazy’ and the state is the ‘meth lab of Democracy,’ then no one is stopping her from packing up and relocating to the liberal utopias of San Francisco or New York where her socialist ideas will fit in better,” NRSC Spokesman Calvin Moore said Friday. “This wasn’t just a one-time, poorly thought out joke, this is a clearly established pattern where Kyrsten Sinema has openly mocked Arizonans and proven she has no respect for the families or voters of this state.”

Meanwhile, Sinema’s opponent, Rep. Martha McSally, R-Ariz., is out this week with a new, positive ad featuring Sen. Jon Kyl, R-Ariz.

“If you’re interested in results rather than resistance and progress instead of protests, join me in voting for Martha McSally,” the senator who replaced the late Sen. John McCain, R-Ariz., says in the new ad.

Sinema enjoys only the slimmest lead over McSally, according to the current RealClearPolitics polling average. If Democrats fail to pick up this seat in Arizona, then there's basically no chance they can win a majority in the Senate this fall.