Supreme Court Justice Amy Coney Barrett denied an opportunity to a group of students who asked the high court to block Indiana University's COVID-19 vaccine mandate.

Barrett, longtime Indiana resident and a Trump appointee, issued no explanation Thursday in declining to refer the students' emergency application for an injunction against the mandate to the full court for review.

The eight applicants appealed their suit seeking to stop the university's vaccine mandate to the high court after losing in the federal district and appellate court.

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The mandate, announced on May 21, requires all students, faculty, and staff to get the vaccine. Students who fail to comply would face "strong consequences," including the cancellation of their class registration, termination of university ID cards, and restrictions on participation in school activities, according to court documents.

The students argued the mandate runs contrary to the conditions of the vaccines' authorizations under emergency use and insisted their objections were "based on legitimate concerns including underlying medical conditions, having natural antibodies, and the risks associated with the vaccine."

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Numerous university systems around the country have mandated that students, faculty, and staff be vaccinated, with some announcing requirements for the shots well before the surge in infections attributed to the delta variant of COVID-19.