Tyrone Gayle, the press secretary to Sen. Kamala Harris, D-Calif., died of colon cancer Thursday evening.

In a statement Friday , the California Democrat said she was "heartbroken" to lose Gayle, whom she said had been "an invaluable and beloved member of our team and our family" since she was sworn in as a senator in January 2017.

“Tyrone started with me on Day 1 in my Senate office and cared so deeply about the people we fight for every day. For Tyrone, nothing was too small to do or too big to take on. He did this work tirelessly, always with a smile or a kind gesture. And he never lost faith in our ability to do good for the people in this country. Tyrone is irreplaceable," Harris said. “We have suffered a great loss and I wish Tyrone’s family — and in particular his courageous wife, Beth — my love and condolences at this difficult time.”

Gayle was diagnosed in 2016 campaign contest, when he was a spokesperson for Hillary for America.

Both former Secretary of State and 2016 Democratic presidential nominee Hillary Clinton and Sen. Tim Kaine mourned the loss.

"He was one of the fiercest fighters we will ever know," Clinton said in a series of tweets. "Whatever he did, he did with his whole heart — whether he was running sprints, planning his wedding to the love of his life, rooting for his beloved Clemson Tigers, or working to build an America as kind, compassionate, and big-hearted as Tyrone himself.

"He spent his 30 years doing all the good he could, in all the ways he could, for as long as he could. Our prayers are with Tyrone’s family, especially his wife, Beth, and their huge community of devoted friends," she added. "We are forever grateful to have known him and will always be proud members of #GayleNation."

Gayle previously worked for Kaine when he ran his successful 2012 Senate campaign. "All who crossed Tyrone’s path were affected by his warmth, humor, and positive energy. Just yesterday, while visiting a Virginia company, I met one of Tyrone’s roommates and track teammates from Clemson and we shared great stories of our friend," Kaine said on Facebook.

Kaine also said it was "one of the honors of my life" to officiate Gayle's wedding to Beth Foster only six months prior.

Online fundraising efforts organized by Jesse Lehrich, who according to Roll Call is a fellow former Clinton spokesman and friend of Gayle's, raised tens of thousands of dollars for Gayle for medical expenses and memorial arrangements.