Democratic nominee Hillary Clinton extended her lead over Republican rival Donald Trump to a record 12 points among U.S. adults, according to a Reuters/Ipsos poll released late Tuesday.

Forty-five percent of respondents who were polled Aug. 18-22 supported the former secretary of state, while 33 percent backed the billionaire businessman.

Clinton led Trump by 3 to 9 points throughout August, but has increased her lead following controversial comments the GOP nominee made in the wake of the Democratic National Convention. A RealClearPolitics poll average gives Clinton a 5-point lead over Trump.

The survey does not take in to consideration a recent shift in the Trump campaign's leadership, messaging and tone. While the GOP leader has begun focusing on policy issues recently, Clinton has been put on the defensive, explaining what is alleged to be a pay-to-play situation between the State Department and Clinton Foundation during her time as secretary of state.

The national survey was conducted online with 1,115 respondents and had a 3 percent margin of error.